Research Scientist, Cellular Immunotherapy, Research & Development

Job Locations US-Florham Park
Research & Early Development
Regular Full-Time


The Research Scientist position is responsible for providing scientific and technical leadership to enable the development of innovative and life-changing cellular immunotherapies within the R&D group. As a member of the Genetically Modified T cell (GMT) team, this scientist will design, execute, and manage studies to support the discovery and development of Immune-Oncology therapeutics to meet regulatory requirements for pre-IND and IND submissions. The successful individual will demonstrate subject matter expertise in molecular, cell, cancer and immune cell biology and hands-on experience in immune cell therapy process and assay development. The position will require an individual with strong analytical, leadership and communication skills (both written and oral) and the ability to work both independently and in a cross functional setting.


  • Key member of the team responsible for the discovery, process development/ definition of cell therapy product candidate(s) (i.e. Chimeric Antigen Receptor T cells), and the establishment and optimization of process/product characterization and functional assays to quality standards.
  • Able to independently design and manage complex experiments with scientific rationale, and critically analyze and interpret data for the discovery and development of novel cell-based cancer immunotherapies.
  • Provide recommendations for and implement studies and strategies to define the phenotypic and functional characteristics of cellular products in pertinent in vitro and in/ex vivo
  • Stay abreast of current literature/ scientific advancements in the field, contribute novel ideas, anticipate technical/experimental challenges, and provide recommendations/solutions for the achievement of R&D objectives.
  • Maintain meticulous laboratory records, electronic files, and laboratory notebooks to support experimental studies and intellectual property development.
  • Work in cross-functional teams and assist other staff members as necessary to complete divisional goals, as required.
  • Ensure the success of team goals through effective interaction with external collaborators, including scientists, CROs, project managers, regulatory and quality assurance experts, and consultants. Monitor and coordinate any outsourced studies to ensure common understanding, compliance with study protocol and timelines, as well as regulatory requirements to achieve high standards of productivity and quality.
  • Responsible for daily laboratory operations, such as maintaining lab equipment/instrumentation and ordering supplies.
  • Maintain a safe and clean work environment in accordance with policies/procedures and OSHA safe laboratory practices.
  • Ensure compliances with GLP regulations in designing protocols, analyzing and interpreting the data and preparing relevant documentation.
  • Author and/or contribute to the writing of protocols, study reports, patents, and peer-reviewed articles to publishable standards.
  • Participate in the preparation of regulatory submission documents.
  • Provide written and oral scientific progress reports to Project Lead and Executive Management, generate scientific publications and intellectual property applications, as required.
  • Present work at project team meetings, internal forums, and external meetings.



  • Strong immunology experience related to Human T cells with solid understanding of advanced concepts and principles in molecular, cellular, cancer and immune biology.
  • Knowledgeable in the areas of T cell development, differentiation, function, and exhaustion.
  • In depth, hands-on experience with mammalian and immune cell culture establishment, expansion, and cell culture techniques including media formulation, cell purification (i.e. Ficoll, magnetic bead separation, cell sorting), cell activation, and cryopreservation.
  • Expertise with genetic modification (CAR expression, viral vector and non-viral based transduction, electroporation/ transfection, and CRISPR-mediated genome editing) of immune cells.
  • Extensive experience in cellular and immune cell-based analytics and assay development including, but not limited to advanced multiparameter flow-cytometry (BD Fortessa/ X20 and/or Cytek Aurora), cell labeling, mixed lymphocyte reactions, intracellular cytokine staining, cell health assays, cell proliferation assays, cytotoxicity assays, cytokine release ELISA/Luminex/ MSD multiplex assays, and single cell RNAseq.
  • Knowledge of laboratory research software applications is required. Ability to use Microsoft Office Suite (Word, Excel and PowerPoint), Graph-pad Prism, and Treestar FlowJo is essential.
  • Must have practical knowledge and/or product development experience in immune and/or cell-based therapies.
  • Detail oriented with the ability to critically interpret and summarize scientific data in an accurate and concise manner and demonstrate competency in defining and initiating next steps.
  • Ability to communicate effectively with colleagues at all levels. Excellent communication skills, both written and oral are essential.
  • Must be goal-oriented with the capacity to handle multiple tasks, manage responsibilities and timelines appropriately, perform highly repetitive procedures, and demonstrate ability to prioritize.
  • Must be able to work both independently and in a project team or matrix setting. Must demonstrate qualities of scientific leadership with ability to collaborate across multidisciplinary teams, both internally and externally.
  • Track record of success as evidenced by a strong publication record, and/or evidence of sustained contributions in the biopharmaceutical industry.


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